hrp0084s5.3 | Developmental Programming: Novel concepts | ESPE2015

Intergenerational Programming of Metabolic Disease via the Paternal Lineage

Patti Mary Elisabeth

Background: Common metabolic diseases, including diabetes and obesity, are the result of interactions between genes and environment. It is well-recognized that the maternal intrauterine environment is an important modifier of this risk. Thus, fetuses carried by women who are obese, diabetic or suffer from suboptimal nutrition are at increased risk of insulin resistance, obesity, type 2 diabetes (T2D), and cardiovascular disease as adults. Emerging data indicate that paternal e...